I was browsing around on del.icio.us and found Dontclick.it. It is a no click interface for web pages. It reminded me of this game for Windows 3.1 that I had when I was a kid, Jewel Thief. In the game the goal was to collect jewels without being touched by a variety of other objects moving across the screen. The user's avatar follows the mouse exactly.
In the web page and the game, annoyance follows when one mouses over the wrong object: the "enemy" avatars or an unintended menu.